A feature article in SCIENCE this week (1) summarized some
very impressive work from Amy Wagers (Harvard) and other researchers on blood
factors that seem able to partially reverse age-related tissue degeneration.
Several groups have used a technique termed parabiosis to establish a shared
circulation between old and young mice.
This resulted in improved function in muscles, heart, and nerves of the
older mice. One possibility is that blood factors from young mice restore the
ability of stem cells in older animals to repopulate damaged tissues. In an
exciting new development Wagers and colleagues have identified a protein termed
GDF11 as the rejuvenating blood factor. GDF11 is a member of the TGB-beta
family of growth factors that regulate many aspects of tissue differentiation
and growth.
These results would seem to
open up new opportunities for clinical approaches that address ageing per se
rather than individual diseases associated with ageing. Some strong arguments
have been made that this approach would make a much greater contribution to
human health and longevity than disease specific therapies (2).
No comments:
Post a Comment