This week the NY Times had
an interesting opinion column on mitochondrial replacement, a procedure
currently under review by the FDA. The idea is that there is a cohort of
inheritable diseases based on defects in the mitochondrial genome. In the
embryo the mitochondria are all derived from the fertilized egg so the defects
are passed from the female partner. Thus the approach for potential parents
where the woman has a mitochondrial defect would be for in vitro fertilization followed by transfer of the fertilized
nucleus to an enucleated egg from a healthy donor. Thus the embryo would have
three parents, the male and female who contribute the nuclear genome and the
female who contributes the mitochondrial genome.
http://www.nytimes.com/2014/02/24/opinion/genetically-modified-babies.html?action=click&module=Search®ion=searchResults%230&version=&url=http%3A%2F%2Fquery.nytimes.com%2Fsearch%2Fsitesearch%2F%23%2Fmitochondrial%2BDNA%2F