The NATURE article reflects a problem that is very familiar to
scientists undertaking review of journal articles (or grant proposals). In the
current ideal model of peer review one is supposed to confine oneself to the
data and methods presented in the submitted article. If these all seem
consistent then one should recommend acceptance of the article by the
journal. However, often one has the
‘gut’ feeling, based on long experience, that something isn’t right, that the
results can’t be valid given the nature of the experiment or the methodology
used. But you can’t just come out and state this in your review! In these cases
reviewers often hunt for some excuse to reject the article, but are sometimes
forced into reluctant acceptance. If more subjectivity were allowed in peer
review it might reduce the frequency of papers, especially high profile ones,
whose data cannot be reproduced upon subsequent analysis (2). This type of
subjective evaluation does take place- in hallway conversations at meetings or
in the university cafeteria, but perhaps there should be more of a place for it
in the formal review process. Eventually flawed research is revealed-
especially if the topic is quite important. However, reputations are not made
by repeating the work of others, and surely here are many observations and concepts
of more modest importance that persist in the literature even though they are
basically incorrect.
(2) http://blogs.nature.com/news/2011/09/reliability_of_new_drug_target.html
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