This blog will deal with the social, economic and public policy implications of contemporary science and technology with an emphasis on biomedical aspects.
Tuesday, November 27, 2012
Are Nanotechnology and Pharmaceutical R & D both about to jump into the pre-competitive pool?
In a thoughtful commentary in NATURE Joshua Pearce discusses how conventional intellectual property strategies (i.e. patent thickets) have hindered the development of commercial nanotechnology. He calls for an open source approach to basic nanotech development similar to the open source software movement. This is a very interesting analysis. It seems that there may a convergent evolution going on in the nanotech industry and the pharmaceutical industry. After decades of focusing almost entirely on internal R&D, big pharma is slowly learning the merits of 'pre-competitive collaboration'. As discussed in previous posts on this blog, there have been several major thrusts in this direction both at level of preclinical research and more recently at the clinical trials level.
Obviously money still needs to be made both in pharma and in nanotechnology; thus allocation of rewards will be important even in more collaborative models of R&D. In an interesting opinion piece in SCIENCE, Garret FitzGerald argues that new intellectual property approaches are also needed in the drug development field. He goes on to describe some novel strategies for sharing rewards in proportion to the contribution to the final product (a marketed drug) rather than being based on the traditional initial composition of matter patent.
On a broader horizon it is interesting that two of the most technologically advanced segments of our economy may be moving toward models that deviate substantially from classic 'dog eat dog' capitalism. Will the 'invisible hand' of the market be supplanted by collaborative helping hands that foster more innovation and broader benefits to society?
http://www.nature.com/news/
http://www.sciencemag.org/content/338/6106/483.full
Tuesday, November 20, 2012
RNAi Feud Is Over
Despite many problems there is still a lot of enthusiasm
about using siRNA for therapeutic purposes. Alnylam and Tekmira are two of the
better companies in the commercial RNAi arena. However, for the last year or so
they have been locked in a legal battle concerning some formulations (termed
Lipid Nanoparticles (LNPs)) used to deliver siRNA. It has been sad to see them
waste resources on a patent squabble at this critical time for the field. Now
apparently this dispute has been settled (see CEN report below). Thus presumably things will move more
smoothly in applying LNPs to deliver siRNA to targets in the liver, where the
technology works great.
But what about targets in organs other than the liver? LNPs
have a dismal record in this context since they are too big to cross capillary
walls in most tissues. Industrial and academic scientists need to work together
to develop some advanced siRNA delivery technologies that will have a broader
reach within the body.
http://cen.acs.org/articles/90/i47/Alnylam-Tekmira-Settle-RNAi-Dispute.html
Wednesday, November 14, 2012
Scientific Career Prospects: Will We Never Learn?
The American Chemical Society recently sponsored a webinar on ' The Doctoral Glut Dilemma', providing an overview of the current dismal prospects for PhD employment. One of the interesting things about this whole issue is the divergence between spokesmen from government and industry who constantly deplore the 'shortage' of talented scientists and technologists, and the experience of recent PhDs who can't find jobs no matter how hard they try. Then of course there are the economists who say that unemployment among PhDs is slightly less then for everybody else so things are not so bad. This is very consoling after you have spent 5 years toiling as a poorly paid graduate student!
This problem is not new. Debates about overproduction of PhDs have been going on since the 1980's, but we never seem to learn.
The answer of course is to engage in academic birth control. The perverse incentives that lead university faculty members to recruit more and more graduate students need to be reversed. The emphasis should be on quality not quantity.
There is much more on this issue in previous posts on the Science for the Future website.
http://acswebinars.org/doctoral-glut
Wednesday, November 7, 2012
Opportunities for the next generation of scientists?
The
election is over. Now the question is whether we will continue on the same
self-destructive course of the past decade or will we start to heal ourselves
and build for the future. Clearly America’s economic success in coming years
will rely more and more on its leadership in science and technology. But where
will that leadership come from? The cutbacks in federal research funding over
the last several years have been devastating to the nascent careers of young
scientists across the spectrum. In my own area of biomedical research funding
percentiles for NIH grants have plummeted to historic lows, with less then 10%
of new grants being funded. This is incredibly stressful for young
investigators, introducing major disruptions and uncertainties both in careers
and in the lives of young families. How can we attract the best and brightest
young people to science and technology when career prospects are so dismal?
To
ameliorate this situation we need to do several things. First, despite the
constrained fiscal climate, our political leaders need to recognize the key
role of science and technology for future economic success and begin to
re-invest in science. Second, our academic institutions need to understand that
they have engaged in a profligate overproduction of science PhDs and that the
emphasis in the future should be on quality not quantity. Third, both academia
and industry need to give some thought to mechanisms to enhance career
stability for scientists so that the loss of a grant or the end of a project
doesn’t mean the end of a career. Maybe this is a pipedream, but if we don’t
take these measures we are going to be rapidly surpassed by nations that take a
longer view of science, technology and economic growth.
Subscribe to:
Posts (Atom)